Using Sequelize in Node.js provides a powerful Object-Relational Mapping solution for interacting with SQL databases through JavaScript objects and methods. As the creator of CoreUI with extensive Node.js experience since 2014, I’ve implemented Sequelize in numerous enterprise applications for robust database operations and data modeling. The most efficient approach involves configuring Sequelize with database connection settings, defining models with associations, and using built-in query methods for data manipulation. This method provides type-safe database interactions while maintaining clean, maintainable code architecture with automatic SQL generation and validation.