Handling form submission in React requires using the onSubmit event handler with preventDefault to control form behavior and process data programmatically. As the creator of CoreUI, a widely used open-source UI library, I’ve implemented form submission handling in thousands of React applications for user registration, data entry, and API interactions. From my expertise, the most effective approach is using controlled components with onSubmit handler that prevents default browser behavior. This method provides full control over form validation, data processing, and user feedback during submission.