Worker threads enable parallel execution of CPU-intensive tasks in Node.js without blocking the main event loop, crucial for computationally heavy operations. As the creator of CoreUI, a widely used open-source UI library, I’ve implemented worker threads in Node.js applications throughout my 11 years of backend development. The most effective approach is using the built-in worker_threads module to offload intensive computations to separate threads. This method maintains application responsiveness while processing complex calculations or data transformations.