JavaScript Set objects provide an efficient way to store unique values and perform collection operations without duplicates. As the creator of CoreUI with over 25 years of JavaScript development experience, I’ve used Sets extensively for managing unique collections in UI components and data processing. From my expertise, the most effective approach is creating Sets with the new Set() constructor and using their built-in methods for adding, checking, and iterating values. Sets offer better performance than arrays for uniqueness checks and provide cleaner syntax for collection operations.