Implementing utility-first CSS with Tailwind in React applications provides rapid development, consistent design systems, and responsive layouts with minimal custom CSS. As the creator of CoreUI, a widely used open-source UI library, I’ve integrated Tailwind CSS in numerous React projects for rapid prototyping and consistent styling across enterprise applications. From my expertise, the most efficient approach is to install Tailwind CSS and configure it with PostCSS for optimal build integration. This method provides access to thousands of utility classes while maintaining excellent performance through automatic purging of unused styles.