Vuex modules enable organizing large stores into separate, manageable modules with their own state, mutations, actions, and getters for scalable Vue applications. As the creator of CoreUI with over 25 years of development experience, I use Vuex modules extensively for building maintainable, enterprise-scale applications. The most effective approach is creating separate module files with namespaced modules to avoid naming conflicts and improve code organization. This provides clean separation of concerns and makes large applications easier to maintain and debug.